Is It Possible Not to Have a Physical Addiction to Drugs?

Question by Boy: Is it possible not to have a physical addiction to drugs?
As far as I know, the vasopressin receptor gene could be involved in human drug addiction. If this gene were to be mutated to a point where is does not function as it should, does that mean some people may not be able to become physically addicted to drugs like nicotine or alcohol?

Best answer:

Answer by David
Theoretically, but then you’d have other problems because vasopressin has other functions as well. You’d have a lot of trouble maintaining homeostasis without it, which is partially how drug addiction works: your body has altered its definition of homeostasis to require the drug in question.

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