How Do TB Drugs Interact With HIV Drugs?
How do TB drugs interact with HIV drugs? – In January, 2012, the US Food and Drug Administration (FDA) issued new guidelines on dosing of an HIV medication used to treat people infected with both HIV and tuberculosis (TB) because of a potential interaction between two of the main drugs used to treat each disease. The drug rifampin, used for treating TB, can lower levels of the HIV medicine efavirenz, so the FDA recommended that patients who weigh more than 50 kg (110 pounds) and who are taking both medications should get 30 percent larger doses of efavirenz (an increase from 600 mg to 800 mg). Now, a new analysis by conducted by researchers with the Adult AIDS Clinical Trials Group (ACTG) at the University of California, San Francisco (UCSF) and the San Francisco General Hospital and Trauma Center (SFGH) suggests this recommended dose adjustment may not be necessary, particularly in non-Caucasian populations. As described in a talk at the XIX International AIDS Conference in Washington, DC on Monday, July 23, 2012, the new FDA guidelines were based on several small studies in European TB patients and one in healthy volunteers, indicating a decrease in efavirenz levels with rifampin. The guidelines were also informed by a mathematical model, which showed that increasing efavirenz to 800 mg when given with rifampin would increase levels to those seen on the regular dose of 600 mg. These data may not apply to patients in African and Asian populations because of genetic differences that lead to higher efavirenz levels …
Shattered Dreams: Bound by Addiction
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A doctor struggling with addiction worries about losing the ability to practice in their chosen field, and risks the reputation of their practice. Many times a typical rehabilitation program will not work, for a number of reasons. Doctors struggling …
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From Financing to Fevers: Lessons of an Antimalarial Subsidy Program
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1Research Scholar, Princeton University, and Director of the Center for Disease Dynamics, Economics and Policy, Washington, DC 20036, USA. 2Professor of Economics … In 2001, the World Health Organization (WHO) recommended that countries use …
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Tuesday's Sports Transactions
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COMMISSIONER'S OFFICE_Suspended minor league free agent OF Joey Gathright 50 games, without pay, for violating the Minor League Drug Prevention and Treatment Program. … MLS_Fined Portland owner Merritt Paulson $ 25,000 for inappropriate conduct …
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